Note: Scoring of VCF files with CADD v1.7 is still rather slow if many new variants need to be calculated from scratch (e.g., if many insertion/deletion or multinucleotide subsitutions are included). If possible use the pre-scored whole genome and pre-calculated indel files directly where possible. We are very sorry for the inconvenience.

How to contact us?

If you have technical problems using CADD, please check the information provided here. If this does not resolve your issues, please contact us at cadd-support [at]

CADD is currently developed by Martin Kircher, Max Schubach, Thorben Maaß, and Lusine Nazaretyan.

Former developers are Philipp Rentzsch, Sebastian Röner, Daniela M. Witten, Gregory M. Cooper, and Jay Shendure.

If you are planning on using CADD in a commercial application, you can obtain a license through the UW CoMotion Express Licensing System. If in doubt about whether you need a license for your application, please contact Jay Shendure and Gregory M. Cooper.