Note: Scoring of VCF files with CADD v1.7 is still rather slow if many new variants need to be calculated from scratch (e.g., if many insertion/deletion or multinucleotide subsitutions are included). If possible use the pre-scored whole genome and pre-calculated indel files directly where possible. We are very sorry for the inconvenience.

CADD scores are freely available for all non-commercial applications. If you are planning on using them in a commercial application, please contact us.

Please upload a VCF file containing up to 100,000 variants

Please provide a (preferentially gzip-compressed) VCF file of your variants. For information on the VCF format see It is sufficient to provide the first 5 columns of a VCF file without header, as all other information than CHROM, POS, REF, ALT will be ignored anyway. The maximum accepted file size is set at 2MB (>100,000 variants for 5 column compressed VCF). If you try to upload files larger than 2MB, you will receive an error ("Connection reset"). You will be able to retrieve your variants faster, if you upload them in smaller sets. The file that will be provided for download is a gzip-compressed tab-separated text file. Make sure that your browser does not alter the file extension (.tsv.gz) during download; otherwise your operating system will not be able to automatically pick the right programs for opening the output. If you need more variants, we suggest downloading the full set of variants.

Please note that by clicking 'Upload variants', you confirm and warrant that you have the full right and authority to provide genomic variant data to CADD, to analyze such data, and to obtain results on such data. You further confirm and warrant that the data does not contain any identifiable information. You also understand that the CADD web server does not require user registration, so that your data is potentially accessible by third parties by decrypting URLs. Finally, you understand that any user data will be removed from the web server periodically, and it is your own responsibility to backup any data and results. You hereby irrevocably agree to hold the developers harmless from any form of liability, even if the data which you provide to CADD becomes compromised.