CADD scores are freely available for all non-commercial applications. If you are planning on using them in a commercial application, please obtain a license. If you have questions, please contact us.

Due to the large file sizes, we highly recommend a download manager or another tool that allows you to continue interrupted downloads (e.g. wget -c). Note that the latest versions also have a separate download option via the install script.

Developmental release: v1.6 [release notes]

Offline scoring scripts for v1.6

Scripts and README for offline installation file (360K)

Genome build GRCh38 / hg38

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh38/hg38 US | DE (81G) US | DE (2.6M)
All possible SNVs of GRCh38/hg38 incl. all annotations US | DE (313G) US | DE (2.7M)
All gnomad release 3.0 InDels to initiate a local setup US | DE (1.1G) US | DE (1.8M)
All gnomad release 3.0 InDels incl. all annotations to initiate a local setup US | DE (7.2G) US | DE (2.5M)
All gnomad release 3.0 SNVs US | DE (5.9G) US | DE (2.4M)
MD5Sums US | DE
All GRCh38 annotations required for offline installation US | DE (206G)

Genome build GRCh37 / hg19

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 US | DE (78G) US | DE (2.6M)
All possible SNVs of GRCh37/hg19 incl. all annotations US | DE (248G) US | DE (2.6M)
48M InDels to initiate a local setup US | DE (591M) US | DE (1.7M)
48M InDels incl. all annotations to initiate a local setup US | DE (3.5G) US | DE (2.4M)
All gnomAD SNVs (release 2.1.1) US | DE (2.3G) US | DE (2.0M)
All gnomAD InDels (release 2.1.1) US | DE (387M) US | DE (1.6M)
MD5Sums US | DE
All GRCh37 annotations required for offline installation US | DE (129G)

Developmental release: v1.5 [release notes]

Offline scoring scripts for v1.4 and v1.5

Scripts and README for offline installation file (360K)

Genome build GRCh38 / hg38

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh38/hg38 US | DE (80G) US | DE (2.7M)
All possible SNVs of GRCh38/hg38 incl. all annotations US | DE (292G) US | DE (2.7M)
80M InDels to initiate a local setup US | DE (948M) US | DE (1.8M)
80M InDels incl. all annotations to initiate a local setup US | DE (6.8G) US | DE (2.4M)
All BRAVO/TOPMed variants (freeze 5) US | DE (5.5G) US | DE (2.4M)
MD5Sums US | DE
All annotations required for offline installation US | DE (168G)

Genome build GRCh37 / hg19

No new model was generated, please use CADD v1.4 for GRCh37.

Developmental release: v1.4 [release notes]

Genome build GRCh38 / hg38

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh38/hg38 US | DE (79G) US | DE (2.7M)
All possible SNVs of GRCh38/hg38 incl. all annotations US | DE (323G) US | DE (2.7M)
80M InDels to initiate a local setup US | DE (948M) US | DE (1.8M)
80M InDels incl. all annotations to initiate a local setup US | DE (8.8G) US | DE (2.5M)
All BRAVO/TOPMed variants (freeze 5) US | DE (5.5G) US | DE (2.4M)
MD5Sums US | DE
All GRCh38 annotations required for offline installation US | DE (194G)

Genome build GRCh37 / hg19

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 US | DE (78G) US | DE (2.6M)
All possible SNVs of GRCh37/hg19 incl. all annotations US | DE (231G) US | DE (2.6M)
48M InDels to initiate a local setup US | DE (588M) US | DE (1.6M)
48M InDels incl. all annotations to initiate a local setup US | DE (3.3G) US | DE (2.2M)
All gnomAD variants (release 2.0.1) US | DE (2.7G) US | DE (2.1M)
MD5Sums US | DE
All GRCh37 annotations required for offline installation US | DE (98G)

Developmental release: v1.3 [release notes]

Description Link (Size) Tabix Index (Size)
1000 phase 3 Genome variants (SNVs and InDels) US | DE (885M) US | DE (1.8M)
1000 phase 3 Genome variants (SNVs and InDels) incl. all annotations US | DE (6.1G) US | DE (2.5M)
1000 Genome variants (SNVs and InDels) US | DE (450M) US | DE (1.6M)
1000 Genome variants (SNVs and InDels) incl. all annotations US | DE (3.3G) US | DE (2.4M)
ESP6500 variants (SNVs and InDels) US | DE (22M) US | DE (524K)
ESP6500 variants (SNVs and InDels) incl. all annotations US | DE (224M) US | DE (632K)
Exome Aggregation Consortium variants (r0.3) US | DE (108M) US | DE (592K)
Exome Aggregation Consortium variants (r0.3) incl. annotation US | DE (954M) US | DE (811K)
SNV variants on Illumina Exome BeadChip US | DE (2.6M) US | DE (408K)
SNV variants on Illumina Exome BeadChip US | DE (33M) US | DE (476K)
All possible SNVs of GRCh37/hg19 US | DE (80G) US | DE (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations US | DE (344G) US | DE (2.7M)
20M InDels to initiate a local setup US | DE (268M) US | DE (1.6M)
20M InDels incl. all annotations to initiate a local setup US | DE (1.6G) US | DE (2.3M)
All annotation tracks required for offline installation of v1.3 US | DE (206G)
Update of the primate WGA data required for offline installation of v1.3 US | DE (3.1G)
Scripts and README for offline installation US | DE (132K)
MD5Sums US | DE

Developmental release: v1.2 [release notes]

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 US | DE (79G) US | DE (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations US | DE (342G) US | DE (2.7M)
1000 Genome variants (SNVs and InDels) US | DE (449M) US | DE (1.7M)
1000 Genome variants (SNVs and InDels) incl. all annotations US | DE (3.3G) US | DE (2.4M)
ESP6500 variants (SNVs and InDels) US | DE (22M) US | DE (532K)
ESP6500 variants (SNVs and InDels) incl. all annotations US | DE (224M) US | DE (650K)
Exome Aggregation Consortium variants (r0.2) US | DE (108M) US | DE (609K)
Exome Aggregation Consortium variants (r0.2) incl. annotation US | DE (954M) US | DE (811K)
SNV variants on Illumina Exome BeadChip US | DE (2.6M) US | DE (418K)
SNV variants on Illumina Exome BeadChip US | DE (33M) US | DE (493K)
20M InDels to initiate a local setup US | DE (267M) US | DE (1.6M)
20M InDels incl. all annotations to initiate a local setup US | DE (1.6G) US | DE (2.3M)
All annotation tracks required for offline installation US | DE (206G)
Scripts and README for offline installation US | DE (132K)
MD5Sums US | DE

Developmental release: v1.1 [release notes]

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 US | DE (80G) US | DE (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations US | DE (279G) US | DE (2.7M)
1000 Genome variants (SNVs and InDels) US | DE (449M) US | DE (1.6M)
1000 Genome variants (SNVs and InDels) incl. all annotations US | DE (3.3G) US | DE (2.4M)
ESP6500 variants (SNVs and InDels) US | DE (22M) US | DE (524K)
ESP6500 variants (SNVs and InDels) incl. all annotations US | DE (224M) US | DE (628K)
Exome Aggregation Consortium variants (r0.1) US | DE (111M) US | DE (592K)
Exome Aggregation Consortium variants (r0.1) incl. annotation US | DE (955M) US | DE (800K)
SNV variants on Illumina Exome BeadChip US | DE (2.6M) US | DE (408K)
SNV variants on Illumina Exome BeadChip US | DE (33M) US | DE (476K)
14M InDels to initiate a local setup US | DE (194M) US | DE (1.6M)
14M InDels incl. all annotations to initiate a local setup US | DE (1.1G) US | DE (2.1M)
All annotation tracks required for offline installation US | DE (206G)
Scripts and README for offline installation US | DE (132K)
MD5Sums US | DE

Published version: v1.0

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 US | DE (79G) US | DE (2.7M)
All possible SNVs of GRCh37/hg19 incl. all annotations US | DE (218G) US | DE (2.7M)
1000 Genome variants (SNVs and InDels) US | DE (445M) US | DE (1.7M)
ESP6500 variants (SNVs and InDels) US | DE (22M) US | DE (643K)
Exome Aggregation Consortium variants (r0.1) US | DE (113M) US | DE (609K)
Exome Aggregation Consortium variants (r0.1) incl. annotation US | DE (656M) US | DE (778K)
Exome Aggregation Consortium variants (r0.3) US | DE (105M) US | DE (609K)
Exome Aggregation Consortium variants (r0.3) incl. annotation US | DE (643M) US | DE (778K)
SNV variants on Illumina Exome BeadChip US | DE (2.7M) US | DE (404K)
12.3M InDels to initiate a local setup US | DE (162M) US | DE (1.7M)
12.3M InDels incl. all annotations to initiate a local setup US | DE (648M) US | DE (2.1M)
MD5Sums US | DE

Earlier developmental release version: v0.5

Description Link (Size) Tabix Index (Size)
All possible SNVs of GRCh37/hg19 US | DE (77G) US | DE (2.7M)
1000 Genome variants (SNVs and InDels) US | DE (448M) US | DE (1.7M)
ESP6500 variants (SNVs and InDels) US | DE (21M) US | DE (643K)
SNV variants on Illumina Exome BeadChip US | DE (2.5M) US | DE (400K)
MD5Sums US | DE