Note: Scoring of VCF files with CADD v1.7 is still rather slow if many new variants need to be calculated from scratch (e.g., if many insertion/deletion or multinucleotide subsitutions are included). If possible use the pre-scored whole genome and pre-calculated indel files directly where possible. We are very sorry for the inconvenience.
CADD scores are freely available for all non-commercial applications. If you are
planning on using them in a commercial application, please obtain a license. If you have questions, please contact us.
Due to the large file sizes, we highly recommend a download manager or another tool that allows you to continue
interrupted downloads (e.g. wget -c).
Note that the latest versions also have a separate download option via the install script.
Offline scoring scripts for v1.7
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (81G)
|
US
| DE
(2.6M) |
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(625G) |
US
| DE
(2.7M) |
| All gnomAD release 4.0 InDels (from genomes only) to initiate a local setup |
US
| DE
(1.2G) |
US
| DE
(1.8M) |
| All gnomAD release 4.0 InDels (from genomes only) incl. all annotations to initiate a local setup |
US
| DE
(11G) |
US
| DE
(2.6M) |
| MD5Sums |
US
| DE |
|
| All GRCh38 annotations required for offline installation |
US
| DE
(336G) |
|
Genome build GRCh37 / hg19
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (79G)
|
US
| DE
(2.6M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE
(562G) |
US
| DE
(2.7M) |
| Liftover gnomAD v4 InDels (from genomes and exomes) to initiate a local setup |
US
| DE (1.4G) |
US
| DE (1.9M) |
| Liftover gnomAD v4 InDels (from genomes and exomes) incl. all annotations to initiate a local setup |
US
| DE (10G)
|
US
| DE
(2.5M) |
| MD5Sums |
US
| DE |
|
| All GRCh37 annotations required for offline installation |
US
| DE
(261G) |
|
Offline scoring scripts for v1.6
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (81G) |
US
| DE (2.6M)
|
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(313G) |
US
| DE
(2.7M) |
| All gnomad release 3.0 InDels to initiate a local setup |
US
| DE
(1.1G) |
US
| DE
(1.8M) |
| All gnomad release 3.0 InDels incl. all annotations to initiate a local setup |
US
| DE
(7.2G) |
US
| DE
(2.5M) |
| All gnomad release 3.0 SNVs |
US
| DE (5.9G)
|
US
| DE
(2.4M) |
| MD5Sums |
US
| DE |
|
| All GRCh38 annotations required for offline installation |
US
| DE (206G)
|
|
Genome build GRCh37 / hg19
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (78G) |
US
| DE (2.6M)
|
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE
(248G) |
US
| DE
(2.6M) |
| 48M InDels to initiate a local setup |
US
| DE (591M) |
US
| DE (1.7M) |
| 48M InDels incl. all annotations to initiate a local setup |
US
| DE (3.5G) |
US
| DE (2.4M)
|
| All gnomAD SNVs (release 2.1.1) |
US
| DE
(2.3G) |
US
| DE
(2.0M) |
| All gnomAD InDels (release 2.1.1) |
US
| DE
(387M) |
US
| DE
(1.6M) |
| MD5Sums |
US
| DE |
|
| All GRCh37 annotations required for offline installation |
US
| DE (129G)
|
|
Offline scoring scripts for v1.4 and v1.5
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (80G) |
US
| DE (2.7M)
|
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(292G) |
US
| DE
(2.7M) |
| 80M InDels to initiate a local setup |
US
| DE (948M) |
US
| DE (1.8M) |
| 80M InDels incl. all annotations to initiate a local setup |
US
| DE (6.8G) |
US
| DE (2.4M)
|
| All BRAVO/TOPMed variants (freeze 5) |
US
| DE
(5.5G) |
US
| DE
(2.4M) |
| MD5Sums |
US
| DE |
|
| All annotations required for offline installation |
US
| DE (168G) |
|
Genome build GRCh37 / hg19
No new model was generated, please use CADD v1.4 for GRCh37.
Genome build GRCh38 / hg38
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh38/hg38 |
US
| DE (79G) |
US
| DE (2.7M)
|
| All possible SNVs of GRCh38/hg38 incl. all annotations |
US
| DE
(323G) |
US
| DE
(2.7M) |
| 80M InDels to initiate a local setup |
US
| DE (948M) |
US
| DE (1.8M) |
| 80M InDels incl. all annotations to initiate a local setup |
US
| DE (8.8G) |
US
| DE (2.5M)
|
| All BRAVO/TOPMed variants (freeze 5) |
US
| DE
(5.5G) |
US
| DE
(2.4M) |
| MD5Sums |
US
| DE |
|
| All GRCh38 annotations required for offline installation |
US
| DE (194G) |
|
Genome build GRCh37 / hg19
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (78G) |
US
| DE (2.6M)
|
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE
(231G) |
US
| DE
(2.6M) |
| 48M InDels to initiate a local setup |
US
| DE (588M) |
US
| DE (1.6M) |
| 48M InDels incl. all annotations to initiate a local setup |
US
| DE (3.3G) |
US
| DE (2.2M)
|
| All gnomAD variants (release 2.0.1) |
US
| DE
(2.7G) |
US
| DE
(2.1M) |
| MD5Sums |
US
| DE |
|
| All GRCh37 annotations required for offline installation |
US
| DE (98G) |
|
| Description |
Link (Size) |
Tabix Index (Size) |
| 1000 phase 3 Genome variants (SNVs and InDels) |
US
| DE (885M) |
US
| DE (1.8M) |
| 1000 phase 3 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (6.1G) |
US
| DE (2.5M) |
| 1000 Genome variants (SNVs and InDels) |
US
| DE (450M) |
US
| DE (1.6M) |
| 1000 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (3.3G) |
US
| DE (2.4M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (524K) |
| ESP6500 variants (SNVs and InDels) incl. all annotations |
US
| DE (224M) |
US
| DE (632K) |
| Exome Aggregation Consortium variants (r0.3) |
US
| DE (108M) |
US
| DE (592K) |
| Exome Aggregation Consortium variants (r0.3) incl. annotation |
US
| DE (954M) |
US
| DE (811K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (2.6M) |
US
| DE (408K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (33M)
|
US
| DE
(476K) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (80G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (344G)
|
US
| DE (2.7M)
|
| 20M InDels to initiate a local setup |
US
| DE (268M) |
US
| DE (1.6M) |
| 20M InDels incl. all annotations to initiate a local setup |
US
| DE (1.6G) |
US
| DE (2.3M) |
| All annotation tracks required for offline installation of v1.3 |
US
| DE (206G) |
| Update of the primate WGA data required for offline installation of v1.3 |
US
| DE (3.1G) |
| Scripts and README for offline installation |
US
| DE (132K) |
| MD5Sums |
US
| DE |
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (79G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (342G)
|
US
| DE (2.7M)
|
| 1000 Genome variants (SNVs and InDels) |
US
| DE (449M) |
US
| DE (1.7M) |
| 1000 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (3.3G) |
US
| DE (2.4M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (532K) |
| ESP6500 variants (SNVs and InDels) incl. all annotations |
US
| DE (224M) |
US
| DE (650K) |
| Exome Aggregation Consortium variants (r0.2) |
US
| DE (108M) |
US
| DE (609K) |
| Exome Aggregation Consortium variants (r0.2) incl. annotation |
US
| DE (954M) |
US
| DE (811K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (2.6M) |
US
| DE (418K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (33M)
|
US
| DE
(493K) |
| 20M InDels to initiate a local setup |
US
| DE (267M) |
US
| DE (1.6M) |
| 20M InDels incl. all annotations to initiate a local setup |
US
| DE (1.6G) |
US
| DE (2.3M) |
| All annotation tracks required for offline installation |
US
| DE (206G) |
| Scripts and README for offline installation |
US
| DE (132K) |
| MD5Sums |
US
| DE |
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (80G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (279G)
|
US
| DE (2.7M)
|
| 1000 Genome variants (SNVs and InDels) |
US
| DE (449M) |
US
| DE (1.6M) |
| 1000 Genome variants (SNVs and InDels) incl. all annotations |
US
| DE (3.3G) |
US
| DE (2.4M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (524K) |
| ESP6500 variants (SNVs and InDels) incl. all annotations |
US
| DE (224M) |
US
| DE (628K) |
| Exome Aggregation Consortium variants (r0.1) |
US
| DE (111M) |
US
| DE (592K) |
| Exome Aggregation Consortium variants (r0.1) incl. annotation |
US
| DE (955M) |
US
| DE (800K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (2.6M) |
US
| DE (408K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE (33M)
|
US
| DE
(476K) |
| 14M InDels to initiate a local setup |
US
| DE (194M) |
US
| DE (1.6M) |
| 14M InDels incl. all annotations to initiate a local setup |
US
| DE (1.1G) |
US
| DE (2.1M) |
| All annotation tracks required for offline installation |
US
| DE (206G) |
| Scripts and README for offline installation |
US
| DE (132K) |
| MD5Sums |
US
| DE |
Published version: v1.0
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (79G) |
US
| DE (2.7M) |
| All possible SNVs of GRCh37/hg19 incl. all annotations |
US
| DE (218G)
|
US
| DE (2.7M)
|
| 1000 Genome variants (SNVs and InDels) |
US
| DE (445M) |
US
| DE (1.7M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (22M) |
US
| DE (643K) |
| Exome Aggregation Consortium variants (r0.1) |
US
| DE (113M) |
US
| DE (609K) |
| Exome Aggregation Consortium variants (r0.1) incl. annotation |
US
| DE (656M) |
US
| DE (778K) |
| Exome Aggregation Consortium variants (r0.3) |
US
| DE (105M) |
US
| DE (609K) |
| Exome Aggregation Consortium variants (r0.3) incl. annotation |
US
| DE (643M) |
US
| DE (778K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE
(2.7M) |
US
| DE
(404K) |
| 12.3M InDels to initiate a local setup |
US
| DE (162M) |
US
| DE (1.7M) |
| 12.3M InDels incl. all annotations to initiate a local setup |
US
| DE (648M) |
US
| DE (2.1M) |
| MD5Sums |
US
| DE |
Earlier developmental release version: v0.5
| Description |
Link (Size) |
Tabix Index (Size) |
| All possible SNVs of GRCh37/hg19 |
US
| DE (77G) |
US
| DE (2.7M) |
| 1000 Genome variants (SNVs and InDels) |
US
| DE (448M) |
US
| DE (1.7M) |
| ESP6500 variants (SNVs and InDels) |
US
| DE (21M) |
US
| DE (643K) |
| SNV variants on Illumina Exome BeadChip |
US
| DE
(2.5M) |
US
| DE
(400K) |
| MD5Sums |
US
| DE |